Biological noise and positional effects influence cell stemness

The Effects of Noise Exposure on Rat’s Hematologic Parameters and Red Cell Indi-ces

Environmental pollution plays a destructive role in the daily life of industrialized communities and due to their negative impact on the society they are always under close investigation.  Besides well-known pollutants substantial, all major international health organizations consider noise pollution as an important health problem.In this study, we have used an animal model to study the effects...

Autophagic control of cell ‘stemness’

Stem cells have the ability to self-renew and differentiate into various cell types. Both cell-intrinsic and extrinsic factors may contribute to aging-related decline in stem cell function and loss of stemness. The maintenance of cellular homeostasis requires timely removal of toxic proteins and damaged organelles that accumulate with age or in pathological conditions. Autophagy is one of the m...

Cell adhesion molecules and their relation to (cancer) cell stemness.

Despite decades of search for anticancer drugs targeting solid tumors, this group of diseases remains largely incurable, especially if in advanced, metastatic stage. In this review, we draw comparison between reprogramming and carcinogenesis, as well as between stem cells (SCs) and cancer stem cells (CSCs), focusing on changing garniture of adhesion molecules. Furthermore, we elaborate on the r...

Single-cell analysis uncovers extensive biological noise in poliovirus replication.

UNLABELLED Viral infections often begin with a very small number of initiating particles. Accordingly, the outcome of an infection is likely to be affected by variability in the initial molecular interactions between virus and host. In this study, we investigated the range of outcomes upon infection of single cells. We isolated individual cells infected with poliovirus at low or high multiplici...

Positional effects in consonant clusters